Pathological evidence in support of total mesorectal excision in the management of rectal cancer.

نویسندگان

  • J V Reynolds
  • W P Joyce
  • J Dolan
  • K Sheahan
  • J M Hyland
چکیده

Some 50 total mesorectal excision specimens were examined following rectal excision for cancer. Circumferential margin involvement was rare, but mesorectal tumour deposits were present in 17 of 44 patients with pT3 tumours, and 23 of 44 had mesorectal nodal involvement. No patient with a pT2 tumour had mesorectal involvement. Failure to excise the mesorectum completely has the potential to leave gross or microscopic residual disease that may in theory predispose to local failure. Total mesorectal excision is necessary to avoid incomplete pathological evaluation of the mesorectum and understaging of rectal cancer.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

New drug in neoadjuvant chemoradiation for rectal cancer

Background: In recent years, neoadjuvant chemoradiation and subsequent surgical resection with total mesorectal excision has been shown to increase local control with decreased toxicity. Neoadjuvant chemoradiotherapy is the standard treatment for locally advanced rectal cancer. In this study we evaluated the efficacy a cox-2 inhibitor on pathologic response, sphincter preservation and acute tox...

متن کامل

The role of total mesorectal excision in the management of rectal cancer.

BACKGROUND Total mesorectal excision (TME) was described 20 years ago and is now being established as the therapeutic gold standard for middle and lower third rectal cancers in a number of countries worldwide. METHODS The authors reviewed published data regarding TME since its first description in 1982. Emphasis was placed on basic principles, achievable recurrence rates, evidence for use of ...

متن کامل

The mesorectum and total mesorectal excision (TME): role of the pathologist in judging the completeness and quality of mesorectal excision

Introduction The best way to optimize rectal cancer patient care is by a multidisciplinary team approach, including a surgeon, a radiologist, a pathologist, a gastroenterologist, a radiotherapist, and a medical oncologist. This leads to significant improvements in the outcome of rectal cancer treatment.1 However, it is a prerequisite that all members of the different medical disciplines of the ...

متن کامل

Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer.

BACKGROUND Short-term preoperative radiotherapy and total mesorectal excision have each been shown to improve local control of disease in patients with resectable rectal cancer. We conducted a multicenter, randomized trial to determine whether the addition of preoperative radiotherapy increases the benefit of total mesorectal excision. METHODS We randomly assigned 1861 patients with resectabl...

متن کامل

New technique of transanal proctectomy with completely robotic total mesorrectal excision for rectal cancer.

Anterior resection with total mesorectal excision is the standard method of rectal cancer resection. However, this procedure remains technically difficult in mid and low rectal cancer. A robotic transanal proctectomy with total mesorectal excision and laparoscopic assistance is reported in a 57 year old male with BMI 32 kg/m2 and rectal adenocarcinoma T2N1M0 at 5 cm from the dentate line. Opera...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • The British journal of surgery

دوره 83 8  شماره 

صفحات  -

تاریخ انتشار 1996